Lancet (London, England)

Effectiveness and safety of combining weekly doses of cagrilintide and semaglutide in type 2 diabetes

Updated

Abstract

The mean change in glycated hemoglobin (HbA) was -2.2 percentage points with CagriSema after 32 weeks.

  • CagriSema demonstrated a greater reduction in HbA compared to cagrilintide (-1.3 percentage points) but not compared to semaglutide (-0.4 percentage points).
  • Participants receiving CagriSema experienced a mean bodyweight reduction of -15.6%, which was significantly more than the reductions seen with semaglutide (-5.1%) and cagrilintide (-8.1%).
  • Fasting plasma glucose levels decreased more with CagriSema (-3.3 mmol/L) compared to cagrilintide (-1.7 mmol/L), but not compared to semaglutide (-2.5 mmol/L).
  • Time in the target glucose range (3.9-10.0 mmol/L) increased significantly with CagriSema from 45.9% at baseline to 88.9% at week 32.
  • Adverse events were reported in 68% of CagriSema participants, with the most common being mild or moderate gastrointestinal issues; no severe hypoglycemia or fatal events occurred.

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Funding

Competing interests

Declaration of interests JPF has received research funding (paid to institution) from 89bio, Akero, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Intercept, IONIS, Janssen, Madrigal, Merck, Metacrine, NorthSea Therapeutics, Novartis, Novo Nordisk, Oramed, Pfizer, Poxel, and Sanofi; is involved with advisory boards and consulting for 89bio, Akero, Altimmune, Becton Dickenson, Boehringer Ingelheim, Carmot Therapeutics, Echosens, Eli Lilly, Gilead, Intercept, Merck, Novo Nordisk, Pfizer, and Sanofi; and has received payment or honoraria for speaker bureaus for Eli Lilly. They are seated on the board of directors in T1D Exchange (non-compensated position). SD, LE, and SM are employed at Novo Nordisk and are stockholders of Novo Nordisk shares. FKK has received research grants (paid to institution) from AstraZeneca, Gubra, Novo Nordisk, Sanofi, and Zealand Pharma; and received personal honoraria for consulting, participating in advisory boards, and/or speaking for 89bio, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Sanofi, Structure Therapeutics, Zealand Pharma, and Zucara. They are a co-founder and minority shareholder in Antag Therapeutics and co-owner of the medical weight-loss clinic Medicinsk Vægttabsbehandling ApS. IL has received research funding (paid to institution) from Boehringer Ingelheim, Merck, Mylan, Novo Nordisk, Pfizer, and Sanofi. They received advisory/consulting fees and/or other support from AstraZeneca, Bayer, Boehringer Ingelheim, Carmot Therapeutics, Eli Lilly, GI Dynamics, Intarcia, Intercept, Johnson and Johnson, Mannkind, Merck, Mylan, Novartis, Novo Nordisk, Pfizer, Sanofi, Shionogi, Structure Therapeutics, TARGETPharma, Valeritas, and Zealand Pharma. CM has received research funding (paid to institution) from the European Commission, FWO, Helmsley Charitable Trust, JDRF, and Novo Nordisk Foundation. They have received honoraria (paid to institution) for consulting, participating in advisory boards, and/or giving lectures/presentations from ActoBio Therapeutics, AstraZeneca, Avotres, Boehringer Ingelheim, Eli Lilly and Company, Imcyse, Insulet, Mannkind, Medtronic, Novartis, Novo Nordisk, Pfizer, Roche, Sandoz, Sanofi, Vertex, and Zealand Pharma; and are Chair of the Board of Hippo and Friends iVZW, Vice President of EUDF, President of EASD, and Chair of the Board of INNODIA iVZW. SDP acted as consultant, advisory board member, and/or speaker for Abbott, AstraZeneca, Bausch, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Pfizer, and Sanofi. They are/have been an investigator in clinical trials funded by AstraZeneca, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Pfizer, Prometic, and Sanofi. MD has acted as consultant, advisory board member, and speaker for Boehringer Ingelheim, Eli Lilly, Novo Nordisk, and Sanofi; an advisory board member for Lexicon, Medtronic, Pfizer, and ShouTi Pharma; and as a speaker for Amgen, AstraZeneca, Napp Pharmaceuticals, and Novartis. MD has received grants in support of investigator and investigator-initiated trials from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Novo Nordisk, and Sanofi-Aventis.
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