Maintenance of cellular ATP level by caloric restriction correlates chronological survival of budding yeast

Caloric restriction extends the chronological lifespan (CLS) of budding yeast by maintaining cellular energy levels.

• Caloric restriction reduced the generation of total reactive oxygen species (ROS) and mitochondrial superoxide.
• Oxidative damage to proteins and DNA was not significantly reduced under caloric restriction.
• Caloric restriction resulted in higher mitochondrial membrane potential (MMP) in yeast cells.
• Consistent ATP levels were sustained during chronological aging in calorie-restricted yeast.
• The findings suggest that caloric restriction enhances the efficiency of energy metabolism rather than primarily reducing oxidative damage.

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