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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Resveratrol supplements for 30 days may mimic calorie restriction effects on energy use and metabolism in obese people
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Abstract
Resveratrol supplementation for 30 days resulted in significant reductions in metabolic rates and lipid levels in 11 healthy, obese men.
- Resveratrol reduced sleeping and resting metabolic rates.
- It activated AMPK and increased protein levels of SIRT1 and PGC-1α in muscle tissue.
- Citrate synthase activity improved without changes in mitochondrial content.
- Intramyocellular lipid levels increased, while intrahepatic lipid content, glucose, triglycerides, alanine-aminotransferase, and inflammation markers decreased.
- Systolic blood pressure lowered, and the HOMA index improved following treatment.
- In the postprandial state, adipose tissue lipolysis and levels of plasma fatty acids and glycerol decreased.
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