Advancing Cancer Treatment: Innovative Materials in PDT and Diagnostic Integration

Jun 5, 2025International journal of nanomedicine

New Materials Improving Light-Based Cancer Therapy and Diagnosis

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Abstract

Nano-systems based on photodynamic materials may enhance tumor diagnosis and treatment.

Early detection and targeted therapy of tumors could significantly slow cancer progression.
Recent advancements in photodynamic nanoparticles show promise for integrated diagnosis and therapy.
New target-specific, highly sensitive, and biosafe nanoparticles are being developed for effective cancer treatment.
Photosensitizer-based materials may facilitate both cancer diagnosis and anti-cancer therapy.
Strategies to optimize nano-systems focus on improving targeting, reactive oxygen species release, and imaging accuracy.

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The diagnosis and treatment of cancers have become a significant challenge in overcoming malignant diseases. Early detection of tumors and timely targeted therapy can greatly impede the rapid deterioration of cancers. In recent years, nano-systems based on photodynamic materials have shown great progress in tumor diagnosis and treatment applications. With the continuous exploration of tumor-specific targets and the development of photodynamic nanoparticles, the generation of new nanoparticles that are target-specific, highly sensitive, and biosafe for integrated diagnosis and therapy is realistic. This review introduces the rational basis for photosensitizer-based materials for integrating cancer diagnosis and anti-cancer therapy, types and characteristics of organic and inorganic photosensitizers currently used for PDT treatment, photosensitive nano-materials with dual detection and therapeutic properties the advancement in developing photo-dynamic nano-systems showing potential in integrated diagnosis and therapeutic applications. We also introduce current strategies for optimizing nano-systems with the properties for enhancing targeting ROS release and accurate imaging, combining therapeutic efficacy, as well as biosafety of the integrative materials for PDT application, providing references for the coordinated optimization of photosensitizer design and clinical translation.

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Abstract

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