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Cardiolipin alleviates insulin resistance by ameliorating mitochondrial dysfunction and promoting fatty acid oxidation
Cardiolipin may reduce insulin resistance by improving energy makers and boosting fat burning
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Abstract
Intragastric administration of cardiolipin at 5 mg/kg lowered blood glucose and improved insulin sensitivity in mice.
- Cardiolipin supplementation is associated with reduced weight gain and alleviated hepatic lipid accumulation in male C57BL/6J mice on a high-fat diet.
- Serum levels of interleukin-6 and low-density lipoprotein cholesterol decreased following cardiolipin treatment.
- Enhanced mitophagy is indicated by a reduction in the LC3-II/LC3-I ratio and Tom20 expression in liver tissue and insulin-resistant HepG2 cells.
- In HepG2 cells, cardiolipin supplementation reduced mitochondrial fragmentation and improved mitochondrial function.
- The expression of fatty acid oxidation-related proteins CPT1A and ACAD1 was upregulated in HepG2 cells treated with cardiolipin.
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