GeneSep 18, 2025

Catalpol’s anti-aging effects linked to increased removal of damaged cell power sources

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Jan 7, 2026

Abstract

Catalpol (CAT) enhances yeast cell viability and extends lifespan through HSP82-dependent mitophagy.

Declines in autophagy function are associated with aging.
CAT, derived from Rehmannia glutinosa, may regulate autophagy to treat age-related diseases.
HSP82 was identified as a key target of CAT through RNA-Seq and bioinformatics analyses.
HSP82 knockout and overexpression experiments suggest that CAT enhances mitochondrial functions.
The findings indicate that CAT's anti-aging effects are linked to its ability to induce mitophagy.

Simplified

Autophagy is an important mechanism for maintaining cell homeostasis, and its decline in function is widely regarded as a key factor in aging. Catalpol (CAT), an active compound derived from the traditional Chinese herbRehmannia glutinosa, has shown potential to treat various age-related diseases through the regulation of autophagy. However, how CAT exerts anti-aging effects by regulating autophagy remains unclear. Therefore, this study sought to explore the anti-aging potential and molecular mechanisms, particularly the role of CAT in autophagy and mitochondrial function in yeast cells. The PI-CLS measurement method was employed to demonstrate enhanced yeast cells viability upon CAT treatment. RNA-Seq combined with bioinformatics analyses identified HSP82 as a key target of CAT. HSP82 knockout and HSP82 overexpression strains were employed to demonstrate that CAT enhances mitochondrial functions and extends cells lifespan by inducing HSP82-dependent mitophagy. We concluded that CAT plays an anti-aging role by regulating HSP82-dependent mitophagy and mitochondrial functions in yeast cells.

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

PubMed

Catalpol’s anti-aging effects linked to increased removal of damaged cell power sources

Abstract

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