Catalpol’s anti-aging effects linked to increased removal of damaged cell power sources

Catalpol (CAT) enhances yeast cell viability and extends lifespan through HSP82-dependent mitophagy.

• Declines in autophagy function are associated with aging.
• CAT, derived from Rehmannia glutinosa, may regulate autophagy to treat age-related diseases.
• HSP82 was identified as a key target of CAT through RNA-Seq and bioinformatics analyses.
• HSP82 knockout and overexpression experiments suggest that CAT enhances mitochondrial functions.
• The findings indicate that CAT's anti-aging effects are linked to its ability to induce mitophagy.

Simplified