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Meta‐analysis of changes in the levels of catecholamines and blood pressure with continuous positive airway pressure therapy in obstructive sleep apnea
Changes in stress chemicals and blood pressure with breathing support treatment in sleep apnea
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Abstract
treatment reduced 24-hour urinary noradrenaline levels by 1.1 in patients with obstructive sleep apnea.
- Continuous positive airway pressure (CPAP) treatment is associated with lower catecholamine levels in patients with obstructive sleep apnea (OSA).
- In randomized control trials, CPAP treatment reduced systolic blood pressure by 4.8 mmHg and diastolic blood pressure by 3.0 mmHg.
- Prospective cohort studies indicated a reduction in systolic blood pressure by 7.5 mmHg and diastolic blood pressure by 5.1 mmHg with CPAP treatment.
- The findings suggest that sympathetic activity may contribute to hypertension linked with stress from OSA.
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Key numbers
-1.1
Reduction in Urinary Noradrenaline Levels
Standardized mean difference in RCTs
4.8 mmHg
Systolic Blood Pressure Reduction
Mean reduction in RCTs
3.0 mmHg
Diastolic Blood Pressure Reduction
Mean reduction in RCTs