Precision approaches to control T cell activation, movement, and self-cleaning by targeting the CD31 immune-metabolism pathway

CD31 (PECAM-1) is a key regulator of immunometabolic pathways relevant to metabolic disease.

• CD31 helps set thresholds for immune activation and coordinates energy use in various cells.
• It restrains T-cell activation and guides T-cell migration.
• CD31 adjusts metabolic reprogramming by balancing glycolysis with mitochondrial function.
• At the vascular-immune interface, CD31 shapes tissue inflammation in conditions like obesity and diabetes.
• Both membrane and soluble forms of CD31 may serve as biomarkers and therapeutic targets.
• Challenges include the complexity of the pathway and variability among individuals.

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