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Abstract
Depressive symptoms occur in a substantial minority of people with amyotrophic lateral sclerosis (ALS).
- Depressive symptoms in ALS may reflect a variety of factors, including psychological burden and sleep disturbances.
- A proposed model suggests that both major depressive disorder (MDD) and ALS could share underlying vulnerabilities related to brain cell activity.
- The relationship between ALS and depression may be influenced by specific cellular processes, such as protein quality control and immune system responses.
- An exploratory analysis aimed to investigate whether certain biological pathways related to nicotinamide mononucleotide (NMN) are connected to the vulnerabilities shared by ALS and MDD.
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