Cureus

Cell Transport and Nerve Signal Package Fragility in Depression and ALS Together: Findings From Nicotinamide Mononucleotide Treatment and Gene Activity Analysis

Updated

Abstract

Depressive symptoms occur in a substantial minority of people with amyotrophic lateral sclerosis (ALS).

  • Depressive symptoms in ALS may reflect a variety of factors, including psychological burden and sleep disturbances.
  • A proposed model suggests that both major depressive disorder (MDD) and ALS could share underlying vulnerabilities related to brain cell activity.
  • The relationship between ALS and depression may be influenced by specific cellular processes, such as protein quality control and immune system responses.
  • An exploratory analysis aimed to investigate whether certain biological pathways related to nicotinamide mononucleotide (NMN) are connected to the vulnerabilities shared by ALS and MDD.

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Funding

Competing interests

Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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