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Abstract
Cellular senescence is a stable cell-cycle arrest triggered by stress factors such as DNA damage and mitochondrial dysfunction.
- Aging is characterized by a gradual decline in physiological function at the organismal level.
- Cellular senescence and aging are distinct but interconnected biological processes.
- The accumulation of senescent cells may contribute to functional decline associated with aging.
- Emerging biomarkers and therapeutic strategies, like senolytics, are being explored to address age-related disorders.
- Understanding the differences and overlaps between aging and cellular senescence could lead to innovative interventions.
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