Cell Aging as a Key Link between Chronic Kidney Disease, Heart Scarring, and Aging
Updated
Abstract
Cellular senescence may connect chronic kidney disease and cardiovascular disease through inflammation and metabolic stress.
- Senescent cells release a pro-inflammatory and pro-fibrotic substance that may contribute to disease progression.
- Persistent senescent cells in kidney and heart tissues could lead to immune-cell infiltration and tissue stiffening.
- Connections between senescence markers and kidney dysfunction, as well as cardiovascular remodeling, are suggested by various human data.
- Current evidence for causality and therapeutic benefit primarily arises from studies in cell cultures and animal models.
Simplified