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Abstract
Cellular senescence is associated with persistent cell-cycle arrest and may contribute to chronic inflammation and age-related disorders.
- Transient senescence plays a role in embryogenesis, tissue repair, and tumor suppression.
- Persistent senescent cell populations accumulate with age due to reduced immune clearance and resistance to cell death.
- Accumulation of senescent cells may promote chronic systemic inflammation, tissue fibrosis, and stem-cell dysfunction.
- Experimental evidence suggests a causal role for senescent cells in various disorders, including cardiovascular and neurodegenerative diseases.
- Early clinical studies indicate potential benefits of senotherapeutic strategies in conditions like idiopathic pulmonary fibrosis and diabetic kidney disease.
- Challenges for clinical application include heterogeneity of senescence, lack of specific biomarkers, and long-term safety concerns.
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