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The role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration
The role of cell aging and possible treatments in spine disc breakdown
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Abstract
Cellular senescence is implicated in the mechanisms of intervertebral disc degeneration (IDD), a common cause of low back pain.
- Cellular senescence significantly impacts the homeostasis of intervertebral discs.
- The review summarizes both the merits and limitations of methodologies used to study cellular senescence in IDD.
- Potential regulatory mechanisms of cellular senescence in IDD progression are explored.
- Therapeutic strategies aimed at inhibiting cellular senescence may help alleviate IDD pathogenesis.
- Challenges and future directions for targeting cellular senescence in IDD treatment are discussed.
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