Full text is available at the source.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide.
- MASLD is characterized by liver fat accumulation, inflammation, and progressive scarring.
- Cellular senescence is identified as a significant factor in the initiation and progression of MASLD.
- Senescence occurs in various liver cell types, including hepatocytes and non-parenchymal cells.
- Senescent cells contribute to disease progression through specific mechanisms and communication between cell types.
- Targeting cellular senescence shows promise as a therapeutic approach for MASLD, although challenges remain.
- Preclinical studies on senolytics and other senescence-targeting strategies face issues with cell diversity and safety.
Simplified