Molecular biology reportsJul 28, 2026

Gene changes linked to cell aging as risk factors for repeated pregnancy loss

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 3, 2026

Abstract

Over half of recurrent pregnancy loss cases remain unexplained.

Recurrent pregnancy loss (RPL) is defined as having two or more pregnancy losses.
Known risk factors contribute to RPL, but many cases are idiopathic.
Investigating molecular and cellular mechanisms may help clarify unexplained RPL cases.
Cellular senescence is a state where cells stop dividing, relevant to reproduction and development.
The role of cellular senescence-related genes in recurrent pregnancy loss requires further evaluation.

Simplified

Recurrent pregnancy loss (RPL) is characterized by two or more pregnancy losses. Despite its etiology encompassing known risk factors, over half of the cases remain idiopathic. In this sense, the search for molecular and cellular mechanisms that could be related to this condition is essential for explaining, at least in part, these cases. Cellular senescence (CS) is a state of cell cycle arrest that is present during reproduction and development; however, its impact on pregnancy remains unclear. Thus, our purpose was to evaluate the involvement of CS-related genes in the RPL context.

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PubMed

Gene changes linked to cell aging as risk factors for repeated pregnancy loss

Abstract

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Funding

Competing interests

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