Aging of Muscle Cells: How It Happens, Its Effects on the Body, and Possible Treatments

Cellular senescence is associated with chronic inflammation and dysfunction in skeletal muscle as individuals age.

• Senescent cells undergo stable growth arrest and exhibit a proinflammatory secretory phenotype.
• Accumulation of senescent cells in skeletal muscle contributes to inflammation, fibrosis, and metabolic dysfunction.
• This process leads to muscle loss, weakness, functional decline, and increased frailty in older adults.
• Molecular drivers and cellular origins of senescence in skeletal muscle impact overall health.
• Emerging senotherapeutic strategies may help improve skeletal muscle health and function in aging.

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