Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies

Cellular senescence is associated with vascular dysfunction and may contribute to the development of cardiovascular diseases.

• Aging leads to vascular dysfunction primarily through arterial stiffening and endothelial dysfunction.
• Key processes driving vascular aging include oxidative stress, chronic inflammation, and reduced nitric oxide levels.
• Cellular senescence is marked by cell cycle arrest and the secretion of inflammatory molecules, known as the senescence-associated secretory phenotype (SASP).
• Excessive senescent cells and the SASP negatively impact vascular function and could be targeted for therapeutic intervention.
• High cellular senescence burden is observed in groups with impaired vascular function, suggesting these individuals may benefit from therapies aimed at reducing senescent cells.

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