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A gene change in collagen that may help worms live longer
Updated
Abstract
Essence
A human centenarian-linked COL25A1 variant may promote longevity through collagen cleavage and immune-related signaling when modeled in C. elegans.
Evidence
In C. elegans, the col-99 S106L -mutant extended lifespan, required p38 MAPK and YAP-1, altered furin-mediated cleavage in vitro, and lifespan extension was reproduced by the cleaved extracellular COL-99 domain.
Caveat
The longevity effect was shown in worms with supporting in vitro cleavage data, not as direct evidence that the same variant extends human lifespan.
Simplified
Key numbers
26%
Lifespan Increase
Lifespan extension in C. elegans with the mutation.
approximately 11%
Mean Lifespan of Mutants
Mean lifespan increase from expressing the of .
Longevity & Aging