Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting

Liraglutide injected into the third cerebral ventricle significantly increased plasma FGF21 levels in free-feeding mice.

• Liraglutide (5-100μg/kg) reduced food intake and body weight in free-feeding mice after 24 hours in a dose-dependent manner.
• Higher doses of liraglutide (50 and 100μg/kg) significantly raised plasma FGF21 levels and liver FGF21 expression.
• Smaller doses of liraglutide (5 and 10μg/kg) did not affect FGF21 levels.
• In food-deprived mice, liraglutide (100μg/kg) resulted in significantly lower plasma FGF21 levels compared to saline control after 24 hours.
• In mice given 1g of food, liraglutide (50μg/kg) also significantly decreased plasma FGF21 levels at 24 hours compared to saline control.

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