Introduction to cerebral cavernous malformation: a brief review

Cerebral cavernous malformations are associated with multiple lumen formation and vascular leakage in the brain capillaries.

• These conditions disrupt the blood-brain barrier, leading to severe neurological symptoms such as seizures and strokes.
• Loss of function mutations in three ccm genes have been identified as contributing factors to the disease.
• The ccm genes are involved in the complex regulation of multiple signaling pathways, including WNT/β-catenin, TGF-β, and Notch signaling.
• CCM research is a growing field that may influence systemic blood vessel permeability and the formation of new blood vessels.

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