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Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice
Activation of the innate immune cGAS-STING pathway linked to Alzheimer's development in 5×FAD mice
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Abstract
The cGAS-STING pathway is activated in the brains of human Alzheimer's disease patients and aged mice.
- The binding of double-stranded DNA by cGAS was detected in the cytoplasm of affected brain cells.
- Activation of the cGAS-STING pathway in microglia was observed in Alzheimer's disease models.
- Cgas;5×FAD mice showed significant protection against cognitive decline and associated Alzheimer's pathology.
- Deficiency of Cgas in microglia reduced neurotoxic effects related to amyloid-β peptides.
- Inhibition of STING using H-151 effectively reduced the activation of the cGAS-STING pathway and improved Alzheimer's disease symptoms in mice.
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