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cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives
cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives
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Abstract
The is linked to neuroinflammation in aging and neurodegenerative diseases.
- Aging may lead to mitochondrial DNA leakage and nuclear DNA damage in the central nervous system.
- This damage could aberrantly activate the cGAS-STING pathway, triggering innate immune responses.
- Activation of cGAS-STING is associated with increased neuroinflammation, potentially heightening the risk for neurodegenerative diseases.
- Neurodegenerative processes, such as protein aggregation, may further stimulate cGAS-STING signaling.
- Amplified cGAS-STING signaling could intensify inflammatory responses and promote cellular senescence.
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