Advanced biologyJun 12, 2024

Activation of a Cellular Defense Pathway Triggers Inflammation and Aging in Immune Cells in Ovarian Endometrioma Caused by Cyst Fluid

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 10, 2026

Abstract

Ovarian endometrioma (OE) fluid can cause a decline in ovarian function, associated with inflammation and mitochondrial dysfunction.

OE fluid is linked to an inflammatory response and cellular aging in ovarian tissues.
Activation of the cGAS/STING signaling pathway may contribute to the negative effects of OE fluid on the ovaries.
The STING inhibitor H-151 can reduce ovarian dysfunction and inflammation caused by OE fluid.
H-151 also appears to prevent mitochondrial dysfunction and cellular aging induced by OE fluid.
These findings suggest potential therapeutic avenues for addressing ovarian dysfunction in the context of endometriosis.

Simplified

Ovarian endometrioma (OE) is a common gynecological condition characterized by the formation of "chocolate cysts". Recent research indicates that the cyst fluid acts as a "toxic environment" for the ovary and plays a significant role in the development of OE, with macrophages being pivotal. However, the specific molecular and cellular mechanisms of it are not fully understood. In this study, clinical samples are integrated, single-cell sequencing, in vivo and in vitro experimental models to comprehensively investigate the effects of OE fluid on ovarian function and the mechanisms of it. Combined with bioinformatics analysis and experimental validation, the findings demonstrate that OE fluid can cause ovarian function decline, which associated with inflammatory response, and mitochondrial dysfunction and cellular senescence, while activating the cGAS/STING signaling pathway. As a STING inhibitor, H-151 effectively alleviates ovarian dysfunction, inflammatory state and cell apoptosis induced by OE fluid. Furthermore, it is also discovered that H-151 can inhibit OE fluid-induced mitochondrial dysfunction and cellular senescence. These findings provide important theoretical and experimental foundations for further research and development of STING inhibitors as potential drugs for treating ovarian dysfunction.

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Activation of a Cellular Defense Pathway Triggers Inflammation and Aging in Immune Cells in Ovarian Endometrioma Caused by Cyst Fluid

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