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Abstract
Chaperone-mediated autophagy (CMA) is linked to cellular alterations that extend beyond the accumulation of damaged proteins.
- CMA is a selective lysosomal degradation pathway that uses a chaperone and a receptor to transport substrates.
- Recent discoveries have identified additional molecular components that participate in CMA.
- Modulation of CMA in vivo shows that it regulates a variety of physiological functions specific to different organs.
- CMA targets both damaged and fully functional proteins, indicating its role in terminating their physiological functions.
- Dysfunction of CMA is associated with ageing and age-related diseases, leading to broader cellular changes.
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