Molecular cancer

Potential of engineered immune cells to treat solid tumors

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Adoptive cell immunotherapy using CARs specific for CD19 has shown remarkable responses in some patients with hematological malignancies.

  • CAR-T cell therapy has limited clinical efficacy in treating solid tumors.
  • Immunosuppression in solid tumors may arise from multiple mechanisms.
  • Strategies to enhance T cell effectiveness in solid tumors are being explored.
  • The review summarizes current approaches to overcome the immunosuppressive environment.

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Funding

Competing interests

ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This is not applicable for this review. CONSENT FOR PUBLICATION: This is not applicable for this review. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
PubMed

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