Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Dec 3, 2024

Changes in eye layer thickness after repeated low-level red-light therapy in children before nearsightedness and how this may predict myopia prevention and control

Regenerative Health Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 19, 2026

Abstract

The average choroidal thickness (ChT) increased significantly at the 3-month visit in participants receiving repeated low-level red-light treatment.

Notable thickening of ChT was observed in the continued and interrupted treatment groups.
The subfoveal ChT showed significant increases, with all changes having P-values less than 0.001.
The area under the curve for predicting satisfactory myopia prevention after 12 months was calculated at 0.983.
Models incorporating gender and 3-month changes in ChT demonstrated strong predictive ability for myopia prevention outcomes.
Using baseline age, gender, and 3-month ChT changes, the models reached a predictive effectiveness of 0.944 for controlling axial length progression.

Simplified

PURPOSE: To investigate longitudinal changes in choroidal thickness (ChT) after 1-year treatment of repeated low-level red-light (RLRL) and their predictive value in efficacy on myopia prevention and myopic shift among pre-myopic children.

METHODS: 278 pre-myopic (-0.50 D < spherical equivalent refraction, SER ≤ 0.50 D) participants were assigned to the RLRL group and control group randomly and evenly. The OCT, visual acuity, AL, SER and other parameters were measured before enrollment and every 3 months after intervention. The data from both eyes of the included participants were analyzed.

RESULTS: A total of 463 eyes were analyzed. Due to the COVID-19 pandemic, 176 participants in the RLRL group had treatment interrupted. The continued RLRL group, interrupted RLRL group and control group were well balanced in baseline characteristics. In the continued and interrupted RLRL group, the average ChT increased significantly at 3-month visit (all P < 0.001) and the subfoveal ChT thickened evidently. The area under the curve (AUC) for the models including gender and 3-month change in ChT to predict satisfactory myopia prevention at 12 months was 0.983. The efficacy of the models that also used the combined indicators of baseline age, gender and the 3-month change in ChT to predict AL progression control over 12 months reached 0.944.

CONCLUSIONS: Continued RLRL intervention induced notable thickening of ChT in premyopic population, especially at the subfoveal sector. For participants received RLRL treatment, the 3-month change in ChT combined with other baseline factors have acceptable predictive discrimination of myopia prevention efficacy.

Full Text

Full text is available at the source.

View Full Text ↗

Changes in eye layer thickness after repeated low-level red-light therapy in children before nearsightedness and how this may predict myopia prevention and control

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week: