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Chronic circadian disruption in adolescent mice impairs hippocampal memory disrupting gene expression oscillations
Long-term sleep cycle disruption in teen mice harms memory and disturbs daily gene activity in the memory system
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Abstract
Adolescent circadian disruption induces impairments in short-term, social, and spatial memory.
- , a form of , is common among adolescents and is linked to reduced academic performance and emotional regulation.
- Chronic chronodisruption was induced in adolescent mice by manipulating light/dark cycles.
- Impairments in memory were observed without an increase in anxiety-like behavior.
- Gene expression analyses showed altered patterns of circadian clock genes in the hypothalamus and hippocampus.
- Changes in daily gene expression patterns were noted for genes related to stress hormone signaling and synaptic plasticity.
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Key numbers
41.54%
Memory Impairment in YJL Mice
Preference for the novel arm in the Y-maze test for controls.
0.336
Discrimination Index in Novel Object Recognition
Control group's mean discrimination index during the NOR test.
5.6 h
Acrophase Advancement in YJL Mice
Acrophase advancement of circadian clock genes in the hypothalamus of YJL mice.