Effects of chronic jetlag on high-fat and high-fructose diet induced renal injury in mice

Chronic jetlag exacerbates obesity-related kidney disease in mice.

• Mice exposed to chronic jetlag combined with a high-fat and high-fructose diet showed increased body weight gain and glucose intolerance.
• Serum lipid levels were significantly elevated in high-fat and high-fructose diet-fed mice.
• Chronic jetlag led to increased urinary protein excretion and aggravated kidney damage, including glomerular hypertrophy and podocyte injury.
• Disruption of renal circadian gene rhythms was observed alongside increased expression of inflammatory markers NLRP3, Caspase-1, and IL-1β.
• There was a positive correlation between the increased inflammatory marker expression and the severity of kidney damage.

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