We canāt show the full text here under this license. Use the link below to read it at the source.
Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut Microecology
Fluoxetine and Butyrate May Relieve Stress-Related Constipation and Change Gut Bacteria
AI simplified
Abstract
significantly alleviated depressive-like behaviors, reducing immobility time by 40%.
- FLX improved gastrointestinal motility, increasing fecal pellet output by 35%.
- Serotonin signaling was restored, with a 2.5-fold increase in serotonin levels.
- Intestinal barrier integrity was enhanced, showing a 60% upregulation of tight junction proteins.
- Gut microbial diversity increased, with a 30% rise in the Shannon index.
- The combination of FLX and produced a 65% improvement in gut motility and a 70% reduction in pro-inflammatory cytokines.
- This combination also achieved an 80% restoration of intestinal barrier function compared to FLX alone.
AI simplified
Key numbers
40%
Reduction in Immobility Time
treatment led to a notable decrease in immobility time.
35%
Increase in Fecal Pellet Output
significantly increased the number of fecal pellets excreted.
65%
Improvement in Gut Motility
- combination achieved a substantial improvement in gut motility.