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Chronobiomaterials for circadian-aligned brain therapeutics
Time-based materials for brain treatments that match the body's daily rhythms
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Abstract
Circadian rhythms regulate daily changes in neural activity, metabolism, and behavior over a roughly 24-hour cycle.
- Disruption of circadian rhythms is commonly associated with neurological and psychiatric disorders.
- Current brain therapies often utilize fixed dosing schedules, potentially overlooking time-of-day variations in treatment effectiveness.
- Recent advancements have led to chronobiomaterials that allow for precise control of therapeutic delivery based on circadian timing.
- These chronobiomaterials include a variety of platforms such as nanoparticles and bioelectronic interfaces.
- AI-enabled approaches may facilitate personalized chronotherapy by adapting treatments in real-time according to circadian rhythms.
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