The Role of Chronopsychiatry in Precision Medicine: Circadian Dysregulation as Diagnostic Marker and Therapeutic Target

Feb 23, 2026Current sleep medicine reports

Using Body Clock Disruptions as a Marker and Treatment Target in Personalized Mental Health Care

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Abstract

, including activity, heart rate, skin temperature, and light exposure, may aid in diagnosing and assessing neuropsychiatric disorders.

Wearable devices that track circadian parameters enhance data collection in psychiatry.
Integrating circadian data into treatment plans may improve personalized approaches for patients.
Therapies aimed at adjusting the circadian system could stabilize sleep-wake patterns.
These findings support the development of precision psychiatry, addressing individual differences in psychiatric disorders.

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PURPOSE OF REVIEW: refers to a research and clinical approach which studies psychiatric illness through the lens of circadian rhythms and aims to reset the body's biological clock to counteract circadian rhythm abnormalities in psychiatric disorders. This review highlights the use of collected from wearable devices and other methods to help the development of personalized treatment plans based on patients' individual circadian functioning. Circadian biomarkers, such as activity, heart rate, skin temperature, and light exposure recorded over 24 h, has shown promise in diagnosing and assessing the severity of various neuropsychiatric disorders.

RECENT FINDINGS: Wearable devices capable of recording multiple circadian parameters have greatly aided data collection, and when integrated into treatment, have shown promise for revolutionizing circadian medicine. Therapies that entrain or shift the circadian system can help stabilize sleep-wake rhythms or better align rhythms with the environment.

SUMMARY: These approaches support the emerging field of precision psychiatry, moving beyond a one-size-fits-all approach and addressing the heterogeneity and complexity of psychiatric disorders.

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The Role of Chronopsychiatry in Precision Medicine: Circadian Dysregulation as Diagnostic Marker and Therapeutic Target

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