[Chronotherapy can be a useful adjunctive therapy in treatment-resistant depression].

Approximately 60% of patients experience high efficacy from sleep deprivation as a treatment for depression.

• Sleep deprivation may provide an early response and is associated with reduced symptoms in patients resistant to drug treatments.
• There is a common occurrence of relapse after sleep deprivation treatment, which presents challenges for patients and healthcare providers.
• Combining sleep deprivation with medications or other therapies may enhance and prolong its effectiveness.
• Despite its potential benefits, sleep deprivation is not widely adopted in Japan due to the lack of financial incentives and the burden it places on patients.

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