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Using timing of treatment to reduce heart damage from anthracycline chemotherapy
Updated
Abstract
Essence
Timing anthracycline dosing to circadian rhythms may help reduce cardiotoxicity, but the best human window remains provisional.
Evidence
This review summarized 3 in vitro, 12 animal, and 9 clinical studies on chronomodulated anthracycline dosing for cardiotoxicity and oncological efficacy.
Caveat
The proposed 3 to 11 AM human dosing window is hypothesized mainly from animal extrapolation rather than direct clinical proof.
Simplified
Circadian Biology