Clinical efficacy of chronotherapy-based auricular acupoint therapy combined with CPAP in comorbid obstructive sleep apnea and insomnia

Significant improvements in sleep quality and respiratory function were observed in patients with comorbid obstructive sleep apnea and insomnia (COMISA) receiving chronotherapy-based auricular acupoint therapy combined with CPAP.

• All treatment groups showed significant reductions in apnea-hypopnea index, hypopnea index, and Epworth Sleepiness Scale scores.
• Notable increases in nocturnal minimum oxygen saturation were recorded across all three groups.
• The auricular acupoint and chronotherapy-based auricular acupoint groups experienced significant reductions in Pittsburgh Sleep Quality Index and Insomnia Severity Index scores after treatment.
• Both intervention groups demonstrated greater improvements in all outcome measures compared to the control group.
• No significant differences were found in respiratory-related indices or nocturnal oxygen saturation between the auricular acupoint group and the chronotherapy-based group, but the latter had better scores in sleep quality assessments.

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