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Abstract
Disruption of the retinal circadian rhythm is associated with oxidative stress and inflammation in retinal diseases.
- Abnormal expression of clock genes and impaired light signaling in intrinsically photosensitive retinal ganglion cells (ipRGCs) characterize retinal disease.
- Rev-erbα and melanopsin form an antagonistic system that regulates the intraocular dopamine-melatonin rhythm.
- Disruption of the dopamine-melatonin rhythm may lead to oxidative stress and inflammation.
- Chronotherapy could be a promising intervention for treating retinopathies linked to circadian misalignment.
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