Clinical Benefits of Circadian-based Antioxidant Protection and Repair

📖 Top 30% JournalDec 21, 2020Journal of drugs in dermatology : JDD

Health Benefits of Antioxidant Protection and Repair Based on Body Clock Timing

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Significant improvements in skin radiance and overall photodamage were observed in 61 female subjects using a novel circadian-based dual serum system.

The active group using the dual serum system showed notable enhancements in skin radiance at weeks 4, 8, and 12 compared to the control group.
Improvements in overall photodamage, tactile toughness, and global fine lines/wrinkles were recorded by week 12 in the active group.
Biopsy results and skin swab analysis corroborated the clinical grading outcomes, indicating a biological basis for the observed improvements.
Subjects consistently rated the dual serum system higher than the control regimen at all follow-up visits, particularly noting improvements in skin radiance and health.

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Skin activities follow endogenous circadian rhythms resulting in differences between daytime and nighttime properties. To address the variations in skin needs, a novel circadian-based dual serum system (LVS) was developed. A 12-week, double-blind, randomized, regimen-controlled, multi-center study was conducted to assess the efficacy and tolerability of LVS on subjects presenting with moderate-severe photodamage. 61 Female subjects (36–65 years; Fitzpatrick skin types I–VI) completed the study. The active group received LVS (daytime serum and nighttime serum) and basic skin care regimen (moisturizer and SPF 35 sunscreen), while the control group received the basic skin care regimen only. In addition to clinical grading, subject self-assessment questionnaires, and standardized photography, punch biopsies were taken in a subset of subjects for immunohistochemistry. Additionally, swab samples were taken for skin surface oxidation analysis. Significant improvements over control were observed in the active group in Radiance (weeks 4, 8, and 12), Overall Photodamage, Tactile Toughness, and Global Fine Lines/Wrinkles (week 12). Biopsy results, skin swab analysis and standardized photographs support the clinical grading findings. At all follow-up visits, LVS was consistently highly rated over control by subjects, with a significant proportion of subjects agreeing at week 12 that LVS "improved the radiance of my skin," and "improved the overall health and look of my skin". Results from this study suggest that LVS may provide essential protective and reparative effects to skin exposed to the damaging effects of environmental factors, and also demonstrates the value of including skin circadian rhythm-based concepts in a topical skincare regimen. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5355.