Prognostic Value of Circadian Brain Temperature Rhythm in Basal Ganglia Hemorrhage After Surgery

Sep 25, 2021Neurology and therapy

Brain Temperature Rhythms May Predict Recovery After Surgery for Basal Ganglia Bleeding

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Abstract

In 55.1% of patients with intracerebral hemorrhage, brain temperature displayed a within 72 hours post-surgery.

The rhythm-adjusted average brain temperature was 37.6 (± 0.7) °C, indicating a diminished mean amplitude.
A shift in the timing of maximum brain temperature was observed in patients after surgery.
Initial age and the presence of a circadian rhythm in brain temperature may predict functional outcomes at 12 months.
Higher average brain temperature is associated with increased survival rates compared to lower average temperatures.

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INTRODUCTION: Intracerebral hemorrhage (ICH) is associated with high mortality and morbidity rates. However, both the rhythmic variation and prognostic value of brain temperature after ICH remain unknown. In this study, we investigated brain temperature rhythm and its prognostic value for post-operative mortality and long-term functional outcomes in patients with ICH.

METHODS: Post-operative diurnal brain temperature patterns at the basal ganglion are described. Following surgery for ICH, 78 patients were enrolled, and intracranial pressure and brain temperature were monitored using a fiber optic device. Brain temperature , amplitude, and acrophase were estimated from the recorded temperature measurements, using cosinor analysis, and the association between these patterns and clinical parameters, mortality, and functional outcomes at the 12-month follow-up were examined.

RESULTS: According to cosinor analysis, brain temperature in 55.1% of patients showed a within 72 h post-surgery. The rhythm-adjusted mesor of brain temperature (± standard deviation) was 37.6 (± 0.7) °C, with a diminished mean amplitude. A temperature acrophase shift was also observed. Multivariate logistic regression analysis revealed that initial age and circadian rhythm of brain temperature appeared to be predictive and prognostic of functional outcomes. Further, patients with higher brain temperature mesor were more likely to survive than those with a lower mesor.

CONCLUSION: For patients with ICH, brain temperature rhythm analysis is an improved prognostic tool for mortality and functional outcome predictions.

Key numbers

8.82×

Increase in Favorable Outcomes

Odds ratio for favorable functional outcomes at 12 months post-surgery.

55.1%

Presence

Percentage of patients showing within 72 hours post-surgery.

37.6 °C

Brain Temperature

Mean brain temperature recorded in patients post-surgery.

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Prognostic Value of Circadian Brain Temperature Rhythm in Basal Ganglia Hemorrhage After Surgery

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