Circadian clock and its effect on aging and lifespan

Jun 27, 2025Biogerontology

How the Body's Internal Clock May Influence Aging and Lifespan

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Aging may impair the functional synchrony of the circadian system, potentially escalating age-related disorders.

Circadian rhythms are driven by periodic changes in transcriptional activators and translational repressors.
Technological advancements and constant work schedules have contributed to an increase in circadian disorders.
Circadian dysfunction is associated with adverse effects on aging and longevity in animal models.
Non-pharmacological interventions, such as dietary restrictions and physical exercise, may regulate circadian rhythms and support healthy aging.
Resetting the circadian clock could improve cellular homeostasis and physiology, potentially leading to increased lifespan.

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The circadian clocks of the cell orchestrate a daily transcriptional rhythm that schedules key activities of the cell to maintain homeostasis and support resilience. Circadian rhythm is driven by the periodic oscillations of transcriptional activators and translational repressors, occurring in both the central and peripheral clocks. Accumulating evidence shows that aging impairs the functional synchrony of the circadian system which further escalate age-related disorders. In addition, the technological aspects of modern society, including constant work schedules and extensive use of personal electronics, have led to a significant rise in circadian disorders. Circadian dysfunction seems to adversely impact aging and longevity in animal models. Therefore, it is essential to conduct comprehensive studies to identify factors that worsen with aging and to discover therapeutic options for promoting healthy aging. This review examines how aging affects circadian function and the reciprocal effects of circadian disruption (CD) on aging and longevity. Further, we highlight the recent findings on non-pharmacological aspects such as dietary restrictions and physical exercise as a regulator of circadian rhythms, aging attenuation, and extending lifespan in mammals. Thus, resetting the circadian clock may lead to better synchrony in cellular homeodynamics and physiology which offers healthy aging and increased life span.

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Circadian clock and its effect on aging and lifespan

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