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Circadian Clock Dysfunction Exacerbate Autistic‐Like Behaviour and Wnt/β‐Catenin Signalling Dysregulation in ASD Mice and Treatment of Melatonin
Disrupted Body Clock Worsens Autism-Like Behavior and Cell Signaling Problems in ASD Mice and May Be Helped by Melatonin
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Abstract
Between 50% and 80% of children with Autism Spectrum Disorder may experience sleep disturbances.
- A potential link exists between Bmal1 deficiency and Autism Spectrum Disorder in mouse models.
- Mice exposed to valproic acid exhibited autistic-like behaviors alongside altered circadian protein expression and disrupted Wnt signaling proteins.
- Bmal1 knockout worsened behavioral changes and further impaired Wnt signaling in valproic acid-exposed mice.
- Melatonin treatment reversed Wnt downregulation and improved behavioral deficits in valproic acid-exposed mice.
- The therapeutic effect of melatonin is associated with its regulation of the Wnt/β-catenin signaling pathway.
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