The Body’s Internal Clock and Its Link to Body Temperature

Body temperature in homothermic animals oscillates daily within a range of 1-3 °C, aiding in synchronizing peripheral clocks.

• Circadian fluctuations in body temperature play a crucial role in maintaining energy balance between day and night.
• Mechanisms affecting body temperature regulation involve heat shock transcription factors and cold-inducible RNA-binding proteins, which influence clock gene expression.
• Poikilotherms actively regulate their body temperature by seeking preferred thermal environments based on their internal clock.
• Flies display a distinct body temperature cycle, demonstrating the influence of their circadian rhythms on thermoregulation.
• Both flies and mice utilize a shared molecular pathway involving calcitonin receptors to regulate body temperature during active phases.

Simplified