Full text is available at the source.
Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption
The internal clock in the brain's fluid-producing area resists immune stress but weakens with disrupted daily rhythms
AI simplified
Abstract
Both chronic light exposure and repeated phase shifts disrupted the circadian clock in the choroid plexus.
- Chronic light exposure dampened the suprachiasmatic nuclei (SCN) clock without shortening sleep duration.
- Repeated phase shifts did not affect the SCN clock but transiently altered sleep duration and fragmentation.
- Both chronodisruption models reduced the circadian clock activity in the choroid plexus (ChP).
- Elevated immune markers were observed in plasma and the hippocampus, but levels in the ChP remained unaffected.
- The ChP clock showed resistance to inflammation induced by lipopolysaccharide treatment.
- Chronodisruption was linked to decreased glucocorticoid signaling in the ChP, indicating its sensitivity to lifestyle changes.
AI simplified