Associations of Circadian Clock Gene Variants with Clinical Features and Treatment Characteristics in Ulcerative Colitis

May 4, 2026Journal of clinical medicine

Links Between Body Clock Gene Differences and Symptoms and Treatments in Ulcerative Colitis

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Abstract

The G allele of the BMAL1 gene variant was found to be more frequent in ulcerative colitis patients (p = 0.028).

Genotype distributions of BMAL1 and CLOCK gene variants were similar between ulcerative colitis patients and healthy controls.
The CC genotype of CLOCK was associated with higher C-reactive protein levels (p = 0.021), indicating increased inflammation.
The TT genotype of CLOCK was linked to a higher likelihood of azathioprine use (p = 0.006) among patients.
These associations suggest that circadian rhythm gene variants may relate to inflammatory activity and treatment needs in ulcerative colitis.

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: Growing evidence suggests that disruption of circadian rhythms contributes to the pathogenesis of inflammation and inflammatory bowel disease; however, clinical data linking circadian gene variants to ulcerative colitis remain limited. In this study, we aimed to investigate associations between key circadian rhythm gene polymorphisms and clinical and treatment-related characteristics in ulcerative colitis.: A total of 107 patients with ulcerative colitis and 80 healthy controls were included in this single-center cross-sectional study. The BMAL1 rs7950226, CLOCK rs1801260, and CRY1 rs2287161 polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype and allele frequency distributions were compared between patients and controls, and associations with clinical characteristics were evaluated within the ulcerative colitis cohort.: Genotype distributions of BMAL1 rs7950226 and CLOCK rs1801260 were similar between patients with ulcerative colitis and healthy controls; however, the G allele of BMAL1 was more frequent in patients (= 0.028). Within the ulcerative colitis cohort, CLOCK rs1801260 genotypes were significantly associated with inflammatory and treatment-related characteristics, with the CC genotype linked to higher C-reactive protein levels (= 0.021) and the TT genotype associated with increased azathioprine use (= 0.006).: These findings suggest a potential association between circadian rhythm gene variants and clinical features of ulcerative colitis, particularly in relation to inflammatory activity and treatment requirements, and provide preliminary clinical insight that warrants further investigation in larger and longitudinal studies. Background/Objectives Methods Results Conclusions p p p

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Associations of Circadian Clock Gene Variants with Clinical Features and Treatment Characteristics in Ulcerative Colitis

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