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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)
How Body Clock Genes Affect Liver Metabolism, Disease, and Treatment
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Abstract
Circadian clock genes may significantly influence liver metabolism and disease progression.
- Disruption of circadian rhythms is associated with the development of various liver diseases, including non-alcoholic fatty liver disease and hepatocellular carcinoma.
- Key circadian regulators, such as circadian locomotor output cycles kaput and brain and muscle ARNT-like protein 1, affect lipid and glucose metabolism, bile acid synthesis, and inflammatory responses.
- Chronotherapeutic approaches like targeted pharmacological treatments and time-restricted feeding could offer new strategies for managing liver disease.
- Further research is needed to understand the mechanisms involved and to facilitate the clinical application of circadian rhythm-based therapies.
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