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Daily body temperature rhythms influence the daily activity of the KCNH2 (hERG) gene controller

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Abstract

Physiological temperature cycles may drive the circadian promoter activity of the cloned human KCNH2 promoter.

  • KCNH2 encodes Kv11.1 channel proteins essential for cardiac repolarization.
  • Two functional isoforms of KCNH2, Kv11.1a and Kv11.1b, are produced through alternative transcription start sites.
  • Kv11.1a is identified as the main factor for cardiac I Kr and ventricular repolarization.
  • The circadian clock influences the expression of Kcnh2 in the mouse heart.
  • Daily body temperature rhythms may synchronize the cardiac circadian clocks.

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