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Abstract
Myocardial infarction and related conditions often occur in the morning and summer, showing more severe symptoms and poorer prognosis.
- disorders may influence the occurrence and development of ischemic heart disease (IHD).
- Abnormal transcription of circadian clock genes is associated with treatment difficulties and poor prognosis in IHD.
- Normal circadian rhythms are linked to neurohumoral regulation and energy metabolism, potentially offering protective roles in IHD.
- HIF1α may connect ischemic heart disease with circadian signaling pathways through specific gene regulation mechanisms.
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