Chronobiology international

Varied growth and increased sensitivity of body clocks to changes in mother’s feeding in a rat model of heart and metabolism disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Significant differences in circadian clock gene expression rhythms were observed in spontaneously hypertensive rats compared to healthy Wistar rats during development.

  • The development of a high-amplitude expression rhythm for the Bmal1 gene was delayed in the suprachiasmatic nuclei and liver of spontaneously hypertensive rats.
  • Atypical circadian clock development in spontaneously hypertensive rats may be linked to differences in maternal behavior detected shortly after delivery.
  • Spontaneously hypertensive rats exhibited higher sensitivity of circadian clocks in the suprachiasmatic nuclei, liver, and colon to maternal feeding regime changes.
  • Maternal restricted feeding shifted the circadian clocks in spontaneously hypertensive rats, even while mothers were kept under a normal light/dark cycle.
  • The diverse development and heightened sensitivity of the SHR circadian system to maternal cues could be associated with their predisposition to cardiovascular and metabolic diseases.

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