Circadian Control of Lipid Metabolism

📖 Top 50% JournalJan 19, 2026Advances in experimental medicine and biology

Daily Rhythms in Fat Metabolism

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Insects have autonomous molecular clocks in key organs involved in lipid metabolism.

Lipid metabolism in insects is influenced by both internal molecular clocks and external environmental cues like light.
Different organs such as the fat body, gut, and oenocytes possess their own molecular clocks, which may operate independently of the central brain clock.
Circadian rhythms affect the levels of lipid metabolites and related genetic expressions in insects.
Certain neuroendocrine signaling pathways are associated with the timing and regulation of lipid metabolism.

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To ensure optimum health and performance, lipid metabolism needs to be temporally aligned to other body processes and to daily changes in the environment. Central and peripheral circadian clocks and environmental signals such as light provide internal and external time cues to the body. Importantly, each of the key organs involved in insect lipid metabolism contains a molecular clockwork which ticks with a varying degree of autonomy from the central clock in the brain. In this chapter, we review our current knowledge about peripheral clocks in the insect fat body, gut and oenocytes, and light- and circadian-driven diel patterns in lipid metabolites and lipid-related transcripts. In addition, we highlight selected neuroendocrine signaling pathways that are or may be involved in the temporal coordination and control of lipid metabolism.

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