Association between circadian disruption and diseases: A narrative review

Oct 3, 2020Life sciences

Links between disrupted body clocks and diseases: a review

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Abstract

Circadian disruption is associated with increased risk for some cardiometabolic diseases.

Circadian rhythms significantly influence various aspects of human health and disease.
Night-shift work and other lifestyle factors may lead to circadian disruption.
Symptoms of circadian disruption can manifest in altered sleep-wake cycles and biological rhythms.
Changes in the sleep-wake cycle, melatonin rhythm, and core body temperature are linked to circadian disruption.
Circadian disruption may occur alongside several psychiatric and neurodegenerative diseases.
Interventions such as phototherapy, melatonin supplementation, and exercise may help mitigate circadian disruption.

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Circadian rhythms play an important role in a wide range of human physiology and pathology. Individuals increasingly experience situations such as night-shift work schedules, likely leading to circadian disruption. Recent studies have also demonstrated that patients with other diseases often show symptoms of circadian disruption as manifested by the sleep-wake cycle and other biological rhythms. Circadian disruption often results in changes to the phase, period, and amplitude of the sleep-wake cycle, melatonin rhythm, and core body temperature. Several cardiometabolic, psychiatric, and neurodegenerative diseases are closely related to circadian disruption. Several interventions are also available, including phototherapy, exogenous melatonin, and exercise. The cumulative findings suggest that circadian disruption can increase risk for some cardiometabolic diseases. Circadian disruption also acts as a concomitant symptom of several psychiatric and neurodegenerative diseases. More attention should be paid to evaluating the impact of circadian disruption on these related diseases, as well as the benefits of the mitigation interventions for both circadian disruption and related diseases.

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Association between circadian disruption and diseases: A narrative review

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