Journal of biological rhythms

How Gene and Environmental Disruptions of Body Clocks Are Linked to Liver Disease Through SRC-2 Function

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Chronic circadian disruption (CCD) and loss of Steroid Receptor Coactivator-2 (SRC-2) in mice are associated with metabolic syndrome and advanced aging.

  • Disruption of daily cycles may lead to severe physiological consequences, including metabolic syndrome and advanced aging.
  • Chronic circadian disruption and SRC-2 ablation in mice resulted in common features of non-alcoholic fatty liver disease (NAFLD).
  • The combination of SRC-2 loss and CCD produced a phenotype resembling human non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).
  • Both CCD and loss of SRC-2 are linked to increased mortality, consistent with findings from other circadian mutant mouse models.
  • SRC-2 is implicated as a crucial link between light cues and metabolic regulation in the liver.

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Competing interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PubMed

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