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Circadian gene BMAL1 attenuates gingival fibroblast senescence to suppress diabetic periodontitis progression
The body clock gene BMAL1 slows aging in gum cells to reduce worsening of diabetes-related gum disease
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Abstract
Diabetes significantly aggravated alveolar bone resorption and accelerated gingival fibroblast senescence in a mouse model of diabetes periodontitis.
- A hyperglycemic environment exacerbates periodontal inflammation and tissue destruction.
- Diabetes and periodontitis exhibit a complex bidirectional relationship that worsens both conditions.
- High glucose and lipopolysaccharide exposure activates the JAK1-STAT3 signaling pathway in gingival fibroblasts.
- Downregulation of brain and muscle ARNT-like 1 (BMAL1) is associated with gingival fibroblast senescence.
- Pharmacological activation of BMAL1 may mitigate senescence and mitochondrial dysfunction in gingival fibroblasts.
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